HORDB

ID: hor005244
Uniprot ID: P06885
Protein name: Big gastrin
Gene name: GAST
Organism: Cavia porcellus (Guinea pig)
Family: Gastrin/cholecystokinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Cavia (genus), Caviidae (family), Hystricomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Mechanism: NA
Cross BBB: NA
Target: CCKBR
Target Unid: H0VZC5
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P06885-F1.pdb

hor005244_AF2.pdb

hor005244_ESM.pdb

Mass:	432817	Formula:	C170H251N45O50S
Absent amino acids:	CIN	Common amino acids:	A
pI:	4.66	Basic residues:	4
Polar residues:	6	Hydrophobic residues:	11
Hydrophobicity:	-80.61	Boman Index:	-5243
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	56.36
Instability Index:	5574.85	Extinction Coefficient cystines:	12490
Absorbance 280nm:	390.31